Network-based functional enrichment
نویسندگان
چکیده
منابع مشابه
EnrichNet: network-based gene set enrichment analysis
MOTIVATION Assessing functional associations between an experimentally derived gene or protein set of interest and a database of known gene/protein sets is a common task in the analysis of large-scale functional genomics data. For this purpose, a frequently used approach is to apply an over-representation-based enrichment analysis. However, this approach has four drawbacks: (i) it can only scor...
متن کاملExtracellular exosomes and preeclampsia: a microarray-based study and functional enrichment analysis
Background: Preeclampsia (PE) is a heterogeneous pregnancy disease which the exact pathophysiology of it is unknown. Recently exosomes have been indicated as a causative factor in the pathogenesis of PE. The aim of the study was to investigate in microarray library data to extract the differentially expressed genes (DEGs) in PE and to perform a functional enrichment analysis to predict the rol...
متن کاملNetwork-based pathway enrichment analysis with incomplete network information
MOTIVATION Pathway enrichment analysis has become a key tool for biomedical researchers to gain insight into the underlying biology of differentially expressed genes, proteins and metabolites. It reduces complexity and provides a system-level view of changes in cellular activity in response to treatments and/or in disease states. Methods that use existing pathway network information have been s...
متن کاملGOMA: functional enrichment analysis tool based on GO modules
Analyzing the function of gene sets is a critical step in interpreting the results of high-throughput experiments in systems biology. A variety of enrichment analysis tools have been developed in recent years, but most output a long list of significantly enriched terms that are often redundant, making it difficult to extract the most meaningful functions. In this paper, we present GOMA, a novel...
متن کاملEnrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
BACKGROUND Gene-set enrichment analysis is a useful technique to help functionally characterize large gene lists, such as the results of gene expression experiments. This technique finds functionally coherent gene-sets, such as pathways, that are statistically over-represented in a given gene list. Ideally, the number of resulting sets is smaller than the number of genes in the list, thus simpl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2011
ISSN: 1471-2105
DOI: 10.1186/1471-2105-12-s13-s14